T-Cell Clonality Screening by PCR
Ordering Recommendation
Aid in the diagnosis of T-cell lymphoproliferative disorders.
New York DOH Approval Status
Specimen Required
Whole blood or bone marrow in lavender (EDTA), tissue, formalin-fixed tissue.
Whole Blood: Do not freeze. Transport 5 mL. (Min: 1 mL)
Bone Marrow: Do not freeze. Transport 3 mL. (Min: 1 mL)
Fresh Tissue: Freeze immediately. Transport 100 mg or 0.5-2.0 cm3 tissue
FFPE Tumor Tissue: Formalin fixed (10 percent neutral buffered formalin) and paraffin embedded tissue. Protect from excessive heat. Tissue block will be returned after testing. Transport tissue block or four 10-micron shavings in a tissue transport kit (ARUP Supply #47808) available online through eSupply using ARUP Connect or contact ARUP Client Services at 800-522-2787.
Whole Blood, Bone Marrow: Refrigerated.
Fresh Tissue: Frozen on dry ice.
FFPE Tumor Tissue: Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.
Plasma, serum. Specimens collected in anticoagulants other than EDTA. Clotted or grossly hemolyzed specimens.
Tissue: FFPE specimens fixed in any fixative other than 10 percent neutral buffered formalin. Decalcified specimens.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Whole Blood or Bone Marrow: Refrigerated: 7 days; Frozen: Unacceptable
Fresh Tissue: Ambient: Unacceptable; Refrigerated: 2 hours; Frozen: 1 year
FFPE Tumor Tissue: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Methodology
Capillary Electrophoresis/Polymerase Chain Reaction (PCR)
Performed
Varies
Reported
5-9 days
Reference Interval
Interpretive Data
Refer to report.
Laboratory Developed Test (LDT)
Note
Hotline History
Hotline History
CPT Codes
81342
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0055567 | T-Cell Clonality by PCR | 21753-9 |
2006285 | T-Cell Clonality Source | 66746-9 |
Aliases
- T Cell Gamma
- T Cell Gene Rearrangement
- T-cell receptor gamma rearrangement
- T-Cell Receptor Gene Rearrangement
- TCRG